The incidence and mortality of Cholangiocarcinoma (CCA) have been increasing in the United States and worldwide for reasons which remain to be determined.CCA is
Defects in repair of single-strand breaks (SSBs) are associated with neurological disease, as illustrated by the hereditary genetic diseases ataxia oculomotor a
Increased microglial activation and neuroinflammation contribute to disease progression in neurodegenerative disorders including Alzheimers disease and Amyotrop
ATM and ATR govern two key DNA damage response (DDR) pathways, which are activated by DNA double strand breaks (DSBs) and single stranded DNA (SSBs)or replicati
Radiation therapy technologies have significantly improved in the last few decades, from initial 2D planning/treatment to the current standard intensity-modulat
Although primordial life is thought to have been RNA-based, organisms now store genetic information in DNA.DNA is a more stable than RNA because ribonucleotides
Genome stability is a prerequisite for the development and function of the nervous system.Multiple DNA damage response pathways ensure that DNA lesions resultin
The development and function of the central nervous system (CNS) is dependent on an effective DNA damage response (DDR), as evidenced by its vulnerability to DD
A hallmark of brain degenerative diseases is impairment of certain aspects of"brain functionality".Brain functionality is defined as the total input and output