PTBP3 Recruits AID to its Targeting Sites to Enable Class Switch Recombination and Genome-wide Mutat

• 作 者: Juan Chen Zhaokui Cai Meizhu Bai Zhe Liu Xiaohua Yu Xihao Hu Ruibao Su Di Wang Jinsong Li Yuanchao Xue
• 机 构: KeylaboratoryofRNAbiology,InstituteofBiophysics,ChineseAcademyofSciences,BeijingShanghaiInstituteofB
• 出 处: 2016遗传学与表观遗传学前沿暨第四届中国青年遗传学家论坛
• 发表日期: 2016年11期

　　Activation induced cytidine deaminase(AID)diversify antibody repertoire through class switch recombination(CSR)and somatic hyper-mutation(SHM)via convergently or divergently transcribed non-coding RNAs in mammalian B cells.Though largely specific in antibody region,AID also non-specifically damage many oncogenes to generate genome translocations and mutations.How AID is recruited to mammalian genome is still a long-standing mystery.Here we reported that RNA binding protein PTBP3 as a key factor to recruit AID to its targets by binding to divergent or convergent non-coding RNAs.