论文部分内容阅读
Objective Radial glia cells (RGCs) play an essential role during corticogenesis, whereas the precise distribution and contribution to cerebral cortex remains less understood.Methods In this research, we used Vimentin as an astroglia marker and Sox2 as a stern/progenitor maker to identify RGCs.Results The Sox2+ cells in E16.5 cerebral cortex germinal zone co-localized with Vimentin or Nestin positive radial processes which extended to the pial surface.In vitro, the E16.5 cerebral cortex-derived Sox2+ radial glia (RG)-like cells shared some properties with RGCs in vivo, and these E16.5 RG-like cells displayed multiple differentiation potentialities.Conclusion Taken together, we identified some characterizations and properties of Sox2+ RGCs derived from rat embryonic cerebral cortex.