【摘 要】
：
Purpose: To analyze toxicity of hypofractionated lung SBRT according to QUANTEC recommendations.Materials and Methods: 44 patients with small primary lung cancer or oligometastasis were treated with S
【机 构】
：
Department of Radiation Oncology, The First Affiliated Hospital Sun Yat-sen University, Guangzhou, C
【出 处】
：
1st International Prostate Cancer Symopsium-2015、1st Interna
论文部分内容阅读
Purpose: To analyze toxicity of hypofractionated lung SBRT according to QUANTEC recommendations.Materials and Methods: 44 patients with small primary lung cancer or oligometastasis were treated with SBRT.Patients were immobilized using SBRT frame.We exported composite dose volume histograms (DVHs) of gross target volume (GTV), planning target volume (PTV) and normal lung tissue (whole lung-GTV).Normal tissue complication probability (NTCP) based on Poisson model was calculated using normal lung DVH, and normalized total dose (NTD) volume histograms were generated at 2 Gy fractions with / =3.7 Gy to account for different fractionations.Variable importance for projection (VIP) and correlation coefficient were calculated using partial least squares regression (PLSR) and logistic regression (LR) to identify prediction factors for normal tissue complications.Results: There were 2 (4.2%) local failures, 4 (9.1%) grade 2 pneumonitis and 3 (6.8%) radiation-induced fibrosis.The <10% pneumonitis rate is in line with QUANTEC report for lung SBRT.5/14 (35.7%) of lesions in fight lower lobe developed complications, in comparison to 1/16 (6.3%) in fight upper and middle lobes, 0/5 (0%) in left lower lobe and 1/11 (9.1%) in left upper lobe.The most influential VIP for predicting complications were mean GTV dose (VIP =1.500, R=0.145) and GTV volume (VIP=1.451, R=-0.140), followed by NTCP (VIP=1.106, R=0.107) although calculated probability was much higher than frequency of complications.LR was able to produce a reasonable NTCP curve for these variables.The predictions factors used for conventional lung RT complications, i.e., V20, VNTD20, mean dose and mean NTD of normal lung had moderate VIP, were negatively correlated to a NTCP logistic curve.Conclusions: Radiation induced complication for SBRT increases with mean GTV dose and cannot be predicted with known prediction factors for conventional lung RT.
其他文献
干细胞研究及其转化应用已经成为各国政府、科研机构和企业界高度关注和大力投入的重要研究领域，是代表国家科技实力的战略必争领域。中国干细胞基础研究近年来已经取得了长足的进展，获得了一批创新性研究成果，几乎连年入选国际、中国十大科技进展；但在干细胞基础理论研究、核心技术开发及转化应用方面与发达国家还存在一定差距，亟需在干细胞研究与转化方面加强布局、加大投入、加快发展，整体提升我国在干细胞基础研究及转化应
杏仁核在对环境威胁的过度防御、恐惧习得有着重要作用.基于以杏仁核为中心的恐惧模型认为,发展为创伤后应激障碍(posttraumatic stress disorder,PTSD)的重要因素之一在于杏仁核的活动增强.本研究选取66名2008年汶川地震的幸存者进行研究,33名创伤后应激障碍患者(PTSD),33名为创伤暴露对照组(control).分别以左、右两侧杏仁核为种子点,与全脑体素进行功能连接
Background: Childhood maltreatment (CM) could increase the risk for developing posttraumatic stress disorder (PTSD) in adulthood, especially for women.But it was unclear about the biological pathway t
研究目的：本研究主要考察脑源性神经营养因子基因多态性(BDNF Val66Met)和压力生活事件以及母亲积极的教养方式的交互作用对青少年特质焦虑的影响,并比较素质-应激模型和差异感受性模型的拟合度.研究方法：样本包含780名11到17岁中国汉族青少年(平均年龄为13.6岁,标准差1.80,51.3％为女性).青少年的特质焦虑,经历的压力生活事件以及母亲温暖推理的教养行为采用自评问卷测量.
目的：分析四川省德阳市某医院有创伤暴露的门诊病人样本中创伤后应激障碍(PTSD)的症状表现及其结构模型.方法：使用创伤历史问卷和DSM-5创伤后应激障碍量表(PCL-5)对631名门诊病人进行施测,筛选出具有创伤经历并有效作答的322人为有效样本,其中男性116人,女生194人,年龄为29.0±11.3岁.对有效样本的PTSD症状进行统计分析,并使用验证性因子分析对6个PTSD症状模型进行检验和比
目的：考察人格与孤独感的关系,并探讨网络使用时间在其中起到的作用.方法：采用大五人格量表(BFI)与简版孤独感量表以及网络使用时间条目对152名学生进行测量,并进行相关与回归分析.结果：①大五人格量表的神经质维度与孤独感呈显著正相关(r=0.25,p＜0.01),外向性,宜人性,责任心和开放性维度与孤独感呈显著负相关(r=-0.26,-0.42,-0.22,p ＜0.01；r=-0.21,p＜0.
Aging in humans is associated with increased differences in cognitivefunction between individuals, which are largely attributed to variability in the brain.However, the fundamental concept regarding i
Studies have shown that depressed individuals experiencecognitive distortions that affected the way they interprettheir environment, including an increased tendency toimpose negative interpretations o
Purpose: Insight is a salient psychotherapeutic progress but has rarely been measured in a controlled experimental setting.This study aims to assess if textual micro-counseling dialogue could validly
Purpose: To use meta-analysis to assess multiparametric magnetic resonance (MP MR) imaging for detection and staging of untreated men with localized prostate cancer.Materials and Methods: We searched