【摘 要】
：
Microglia are resident immune cells in the central nervous system (CNS).In response to injury or inflammatory stimuli, the resting microglia can be rapidly
【机 构】
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Zhejiang University School of Medicine, Hangzhou 310058, China
【出 处】
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中国神经科学学会第九届全国学术会议暨第五届会员代表大会
论文部分内容阅读
Microglia are resident immune cells in the central nervous system (CNS).In response to injury or inflammatory stimuli, the resting microglia can be rapidly activated to participate in pathological responses, including migration to the affected site, release of various inflammatory molecules, and clearing of cellular debris.ATP released from damaged neural cells has been considered to be a major chemokine for inducing rapid process extension and migration ofmicroglial cells.However, ATP leaking from the local injured cells may not be able to diffuse extensively to effectively induce migration of remote microglia, because extracellular nucleotides are rapidly degraded by ecto-ATPases in the brain.We found that ATP-induced ATP release from microglial lysosomes contributed to the directional migration of remote microglia.In addition, we found that ATP could function as a "drink" signal in microglia by triggering macropinocytosis.Interestingly, we found that this purine-induced macropinocytosis is very efficient in clearing up extracellular soluble amyloid beta (Aβ), an early and key intermediate in the pathogenesis Alzheimers disease.
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