NO-aspirin Induces Cell Death in Acute Lymphoblastic Leukemia through TNF-RI and Caspase-10 in a Lig

• 作 者: LindaBendall;
• 机 构: Senior Research Fellow Westmead Institute for Cancer Research Westmead Millennium Institute Universi
• 出 处: 2011第四届世界癌症大会
• 发表日期: 2011年期

　　Although patients with acute lymphoblastic leukemia (ALL) usually achieve complete remission, disease relapse is common and difficult to treat, necessitating new strategies for the treatment of ALL.NO-aspirin is a novel drug that has efficacy against a number of solid tumors.This drug can inhibit Wnt signaling, which we have shown to be important for ALL cell proliferation and survival.Treatment of B lineage ALL cell lines and patient ALL samples with NO-aspirin resulted in rapid apoptotic cell death.