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Cortical neural progenitor cells (NPCs) change their competency over time during development,giving rise to distinct cell types sequentially.Many genes that govern cortical development are now known,but it remains elusive how their temporal expression is controlled.Recently,long non-coding RNAs are found to be essential for cell-fate specification and precise gene regulation in many developmental events.In this study,strand-specific RNA sequencing studies unveil large amount of long non-coding RNAs are actively and differentially expressed across mouse cortical development.Integration of RNA sequencing data from key stages of developing mouse cortex enables us to cluster coding and non-coding transcripts into co-expression "modules" to infer functional relationships.