Overall Survival Endpoint in Oncology Clinical Trials: Addressing the Effect of Crossover

来源 :2016第九届世界癌症大会 | 被引量 : 0次 | 上传用户：shi2879999

【摘要】

：

To identify the issues of using overall survival (OS) as a primary endpoint in the presence of crossover and the statistical analyses available to adjust for confounded OS due to crossover in oncology

【作者】

：

Jose Diaz

【机构】

：

Worldwide Health Economics and Outcomes Research Bristol-Myers Squibb USA

【出处】

：

2016第九届世界癌症大会

【发表日期】

：

2016年7期

下载到本地 , 更方便阅读

下载此文赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

其他文献

Evaluation of careHPV and LBC for Detection of CIN2+ in Rural Area,China

In China,prevalence of cervical cancer is very high among the Uyghurs,an ethnic minority in Xinjiang Uyghur Autonomous region.This study evaluates the performance of careHPV,and Liquid Based Cytology

会议

Hyperactivated Signaling Pathways of Chemokine RANTES/CCL5 in Osteopathies of Jawbone in Breast Canc

Hollow spaces in jawbone have been defined as fatty degenerative osteonecrosis of jawbone (FDOJ) and have been linked with a deregulated immune system.Little is known about the underlying relationship

会议

A Novel Phosphotyrosine Switch Regulates Antitumor Activity of Estrogen Receptor-beta

Estrogen receptors ERα and ERβ share considerable sequence homology yet exert opposite effects on breast cancer cell proliferation.While the proliferative role of ERα in breast tumors is well characte

会议

Alpha5-nAChR Mediates Nicotine Signaling Contributions to Lung Cancer

The use of tobacco products is associated with an increased incidence of cancers.Nicotine and its associated nicotinic acetylcholine receptors (nAChRs) are known to be involved in the progression of c

会议

Cancer Cells with Dysfunctional Mitochondria Restore Their Mitochondrial Function and Tumorigenic Ca

Mitochondrial DNA (mtDNA) is critically involved in tumorigenesis/metastasis;loss of mtDNA correlates with loss of tumorigenicity of cancer cells and their poor growth.

会议

Role of Hepatic Cytochrome P450 Enzymes in the Bioactivation and Detoxication of Aristolochic Acid

Aristolochic acids (AAs) is known to be a potent mutagen and carcinogen.Hepatic cytochrome P450s (CYPs) play an important role in the metabolism of AAs.

会议

Genes Mutations on B Cell Receptor Signaling Pathway in DLBCL Patients and the Significance for Clin

Activated B-cell-like diffuse large B cell lymphoma (ABC-DLBCL) cells require constitutive NF-B signaling for survival.Recent studies have shown that B-cell receptors (BCRs) activate NF-B and that chr

会议

Genetic Variations in Genes of Tricarboxylic Acid Cycle Key Enzymes and Cancer Prognosis

Metabolic reprogramming is a hallmark of cancer,including the alterations of tricarboxylic acid (TCA) cycle key enzymes in the mitochondrial metabolic pathway.

会议

Autocrine Regulation of the Glioma Initiating Cells

Glioblastoma (GBM) is a highly infiltrative and incurable primary brain tumor.Despite aggressive therapy,patients with GBM have a dismal prognosis with median survival of about 1 year.

会议

The Role of Vitamin D in Cancer Prevention

Vitamins have been documented to have a preventative role against cancer.Current research from invitro,invivo animal models and epidemiological studies suggest that Vitamin D specifically may have a v

会议

Overall Survival Endpoint in Oncology Clinical Trials: Addressing the Effect of Crossover

其他学术论文