Resolving Chromosome-centric Human Proteome with Translating MRNA Analysis: a Strategic Demonstratio

• 作 者: JiayongZhong;YizhiCui;JiahuiGuo;GuibinWang;XingfengYin;Qing-YuHe;GongZhang;TongWang;
• 机 构: Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes,Institute of
• 出 处: 第八届中国蛋白质组学大会
• 发表日期: 2013年期

　　Chromosome-centric human proteome project(C-HPP)aims at differentiating chromosome-based and tissuespecific protein compositions in terms of protein expression,quantification and modification.We previously found that the analysis of translating mRNA(mRNA attached to ribosome-nascent chain complex,RNC-mRNA)can explain over 94%of mRNA-protein abundance.Therefore,we propose here to use RNC-mRNA information to illustrate protein expression both qualitatively and quantitatively.