Butyrate inhibits interleukin-17 and generates Tregs to ameliorate colorectal colitis in rats

• 作 者: Mingming Zhang Qian Zhou Dorfman RG Tingting Fan Hao Zhang Jun Zhang Chenggong Yu
• 机 构: Department of Gastroenterology, Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing Univ
• 出 处: 第十一届全国肠道疾病学术大会暨2015天津消化内镜年会
• 发表日期: 2016年8期
• 关键词: butyrate inflammatory bowel disease cytokines Th17 Treg

　　Background and Aims: Butyrate is an energy source for colonocytes that is formed by bacterial fermentation of dietary fiber in the colon and that exerts broad anti-inflammatory activities.Although the administration of butyrate improves homeostasis in patients and ameliorates IBD-related lesions and symptoms,the anti-inflammatory mechanisms of butyrate still remain unclear.To explore the impact of butyrate on Treg/Th17 differentiation and colitis in rats.Methods: The effect of butyrate on the expression of markers related to both Tregs and Th17 cells were determined in human monocytes as well as a rat model of colitis induced by 2,4,6-trinitrobenzene sulfonic acid.Rats were treated with butyrate in vivo,whereas the rat splenocytes and human monocytes were treated in vitro.