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The pandemic influenza A (H1NI) has been a great deal of concern all over the world.On June 11.2009, the WHO declared the outbreak a pandemic.Indeed, it is an emergent and important issue to develop a methodology to provide effective preventions and treatments for the swine flu and other possible infectious diseases.Theoretical epidemiology [1] has been developed for clarifying the mechanism of spread of infection and estimating efficacy of possible interventions in combination with clinical epidemiology.Although simple mathematically tractable models have been widely used.the assumptions behind such a model are sometimes not realistic.Therefore.it is expected to extend mathematical models by taking into consideration complex networks of transmission, heterogeneity of populations, unsteady factors like seasonal variability and temporal interventions.