OBJECTIVE:To investigate the effect of manual acupuncture (MA) at single and combined acupoints on gastric motility and vagus nerve discharges..METHOD:In anesthetized Sprague Dawley (SD)rats,the gastr
Parkinsons disease (PD) is a progressive neurodegenerative movement disorder,which caused predominantly by the degeneration of the nigrostriatal dopaminergic pathway.Lateral habenula (LHb) has efferen
目的:观察apelin-13 是否通过影响ABCA1 蛋白水平从而调节Aβ 代谢。方法:①Western blot 检测PC-12细胞血管紧张素受体AT1 相关的受体蛋白(putative recep tor p rotein related to the angiotensin recep tor AT1,APJ)表达,以确定PC-12 细胞存在apelin-13 作用受体。
The present research investigated the effect of emodin on trigeminal neuralgia mediated by P2X3 receptor and CGRP.The trigeminal neuralgia rat model(a chronic constriction injury of the infraorbital b
NMDARs and ASIC1a both exist in central synapses and mediate important physiological and pathological conditions,but the functional relationship between them is unclear.Here we report several novel fi
Depression is highly prevalent in individuals with diabetes and the depressive symptoms are less responsive to current antidepressant therapies.Oxidative stress plays a major role in both the pathogen
Long-term depression of inhibitory responses (LTD),as mediated by endocannabinoid (eCB),plays an important role on presynaptic plasticity in the mammalian brain.However,the involvement of eCB on the d
Formaldehyde (FA) has neurotoxicity and we have previously demonstrated that hydrogen sulfide (H2S),the third gasotransmitter,antagonizes FA-induced neurotoxicity.However,the exact mechanisms underlyi
Fear conditioning is an associative learning in which a conditioned neutral stimulus is paired with an aversive unconditioned stimulus to elicit fear response.Repeated exposures to conditioned stimulu
Cell-type specific differences in the kinetics of inhibitory postsynaptic conductances (IPSCs) impact upon network dynamics throughout the brain.Much attention has been focused on how GABAA receptor a