Flexible cefalexin-immobilized graphene oxide film for antibacterial and drug delivery

• 作 者: Zhou-cheng WANG Xun Xu Bin-bin WEI Zheng-bing QI
• 机 构: College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China
• 出 处: 第十一届全国表面工程大会暨第八届全国青年表面工程学术会议
• 发表日期: 2016年4期
• 关键词: Graphene oxide Chemical synthesis Thin films Drug delivery Antibacterial

　　Graphene, a unique carbon material comprises two-dimensional one-atom-thick carbon atoms hexagonally arranged into a 2D structure. It has become one of the most attractive function materials in some areas because of its brilliant mechanical and electrical properties. Graphene oxide (GO), an important derivative of graphene, has inherited some unique properties from graphene. Additionally, it contains plentiful kinds of functional groups, such as hydroxyl, carboxyl, epoxide and carbonyl groups on its surfaces. Due to the functionalized surfaces, water-solubility and high specific surface area, GO and its derivatives have been researched as potential biological materials in recent years. In this work, the flexible and freestanding graphene oxide (GO) film was fabricated for drug delivery and antibacterial. The film was synthesized by covalently attaching cefalexin onto graphene oxide sheets and then made by filtration of the colloidal suspension. ATR-FTIR spectra suggest that cefalexin molecules have grafted onto the GO surface and the amide bond is formed. SEM and optical images show that the Cefalexin-grafted graphene oxide (GO-CE) film possesses the unique 2D layer-by-layer structure and it could form channels for drug release when immersed in water. The drug loading and release tests certify that the GO-CE film is a promising drug delivery membrane with high load capacity (0.621 mg mg-1) and long-acting release properties (72 h), and can effectively inhibit the growth of E. coli and S. aureus bacteria while showing min mal cytotoxicity for a long time. The cellular culture results of the HeLa Cells indicate that the GO-CE film exhibits excellent biocompatibility. Based on these advantages, the GO-CE film is expected to be used in the environmental and medical applications.