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目的:观察小檗碱对阿霉素性心肌细胞凋亡的影响及作用机制。方法:利用乳鼠心肌细胞和SD大鼠复制阿霉素性心肌损伤模型,测定阿霉素和小檗碱处理后心肌细胞凋亡与相关信号通路的变化。结果:小檗碱减轻阿霉素引起的乳鼠心肌细胞
Objective: To observe the effect of berberine on doxorubicin-induced cardiomyocyte apoptosis and its mechanism. Methods: Adriamycin-induced myocardial injury was induced in neonatal rat cardiomyocytes and SD rats, and the changes of cardiomyocyte apoptosis and related signal pathways after adriamycin and berberine treatment were determined. Results: Berberine attenuates doxorubicin-induced neonatal rat cardiomyocytes