Inhibition of Na+/H+exchanger 1 by caripodde reduces Burn-Induced Intestinal Barrier Breakdown

• 作 者: XuekangYang;JiChen;HuaBai;KeTao;QinZhou;HongyiHou;DahaiHu;
• 机 构: Department of Burns and Cutaneous Surgery,Xiiing Hospital,The Fourth Military Medical University,Xi
• 出 处: 第十届全国烧伤救治专题研讨会暨福建省第八次烧伤外科学术研讨会
• 发表日期: 2013年期

　　Severe burns initiate an inflammatory cascade within the gut,which leads to intestinal mucosal injury Although the Na+/H+exchanger 1 (NHE1) is recognized as a pivotal player in several inflammatory processes,its role in burn-induced intestinal injury is relatively unknown We hypothesized that NHE1 might be involved in the increased intestinal permeability and barrier breakdown after severe burns.Thus,we here investigate whether the inhibition of NHE1 has a protective effect on burn-induced intestinal injury Mice were subjected to a 30%total body surface area(TBSA)full thickness steam burn.