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In recent years,brain science has been extensively studied in the world and one of the method is based on near-infrared spectroscopy(NIRS).The earlier study found that near-infrared light could penetrate the scalp,skull,cerebrospinal fluid and reach the cerebral.Different from other tissues,brain tissues had its special properties because cerebrospinal fluid was liquid.We are going to research its luminous flux changes influenced by light transport.In this paper,we did Monte-Carlo simulation to explore the luminous flux changes of brain tissue based on different detecting radius and different cerebrospinal fluid thickness.First of all,we established a brain tissue model of five layers and set optical paremeters of each layer.Second,ten samples with different detecting radius were simulated by Monte-Carlo method to find the best detecting radius for brain study.Moreover,the effective detecting depth of every sample was recorded.Similarly,eight samples with different thickness of cerebrospinal fluid were simulated.We got the luminous flux of sample on the model surface.Finally,the simulation results were compared.It was found that diffuse light transport could be influenced by detecting radius and cerebrospinal fluid.With the increase of detecting radius,the effective detecting depth increased.When the thickness of cerebrospinal fluid increased,the luminous flux of sample on the surface was increasing.This research clearly found that the relationship between diffuse light,detecting radius and cerebrospinal fluid was regular.The results will be helpful in the development of brain research and be meaningful to medical diagnosis.