【摘 要】
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Objectives: To study the effects of sanqi sodium hyaluronate gel on the expression of tissue inhibitor of metalloproteinase-1 (TIMP-1) and matrix metalloproteinase-l(MMP-1) in the formation of rabbits
【出 处】
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第四届传统医学与现代医学比较国际学术大会暨中国中西医结合学会呼吸病专业委员会2015工作会议
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Objectives: To study the effects of sanqi sodium hyaluronate gel on the expression of tissue inhibitor of metalloproteinase-1 (TIMP-1) and matrix metalloproteinase-l(MMP-1) in the formation of rabbits epidural scar.Methods: Ninety-six New Zealand White rabbitswere randomly assigned into the saline,sanqi, sodium hyaluronate (SH), sanqi sodium hyaluronate gel (SSHG)groups (n=24).The laminectomy of rabbit was performed, and 0.5 mL of saline saline, concentrated sanqi solution, sodium hyaluronate, or sanqi sodium hyaluronate gel was injected around dural sac,respectively.In-situ hybridization was applied for evaluations of TIMP-1 and MMP-1 at 1, 2,and 4 weeks after operation.Results: In SSHG group, the expression of TIMP-1 was significantly lower and the expression of MMP-1 was significantly higher than those in the other groups, at 2 and 4 weeks after operation (P<0.05).Similarly at 2 weeks after operation, significant improvements in Sanqi group and SH group were seen, compared to those saline group (P<0.05).Conclusion: Sanqi sodium hyaluronate gel can inhibit the activity of TIMP-1, stimulate the expression of MMP-1, and accordingly reduce the scar fibrosis.
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