Background and Aims:The"Metroticket"prognostic model for survival after liver transplantation (LT) for hepatocellular carcinoma (HCC) treatment has been implemented for several years.The aim of our st
Background & Aims:Activating transcription factor 3 (ATF3) is a stress-induced transcription factor that has been shown to repress inflammatory gene expression in multiple cell types and diseases.Howe
Objective:To evaluate the clinical efficacy of adjusting tacrolimus dosage according to CYP3A5 genotype in liver transplant patients.Methods:In 2012,106 liver transplant patients were enrolled continu
Background:Liver transplantation (LT) is an optimal choice for patients with acute on chronic liver failure (ACLF),with reported survival rates of around 80％.Little is realized about the significance
Aim:Accumulating evidence from experimental and clinical studies indicated that platelets can improve liver function by mediating liver regeneration.We embarked on the current study to determine the r
Aim:Many studies have confirmed that serum cholesterol concentration was associated with underlying fiver damage and reflected the synthesis capacity of liver.However,the role of cholesterol level on
Background:Tumor recurrence after liver transplantation (LT) for hepatocellular carcinoma (HCC) remains the major obstacle for long term survival.Objective:To evaluate the efficacy and necessity of ad
Aims:Explore a new diagnosis and treatment model to improve the overall therapeutic effect of ischemic-type biliary lesions (ITBLs) after orthotopic liver transplantation (OLT).Methods:Our center has
目的:在1型糖尿病治疗上,尽管目前已经普及了血糖监测和胰岛素的规范化使用,但仍有许多患者无法控制血糖,甚至出现严重的低血糖反应.而胰岛移植通过重建患者血糖生理性调控功能,避免了因胰岛素使用引起的低血糖反应,降低了糖尿病并发症,同时减少了生活中服药及注射胰岛素的麻烦,是一种非常有前景的治愈1型糖尿病的手段.目前认为,人胰腺分离胰岛每例达到约200000IEQs以上即可达到一次临床移植的量.而一般的纯
目的:肝脏细胞移植可以有效缓解肝硬化、肝衰竭等肝脏疾病病情.原代肝脏细胞在体外不能传代培养,无法获得足量的细胞进行细胞移植.诱导多能干细胞(induced pluripotent stem cells,iPSCs)能够在体外维持自我更新并具有多向分化的潜能,该类细胞在体外可以定向分化为肝脏细胞.本实验旨在无血清培养环境下利用细胞因子诱导的方法使iPSCs向肝细胞定向分化,获得大量能够进行细胞移植的