Identification of annexin 1 as a formyl peptide receptor agonist released by necrotic human glioblas

• 作 者: YanYang[1]JianHuang[2]WangHuaGong[3]YingLiu[4]KeQiangChen[4]JiMingWang[4]
• 机 构: Laboratory of Molecular Immunoregulation, Cancer and Inflammation Program, Center for Cancer Researc
• 出 处: 泛环渤海地区(七省二市)生物化学与分子生物学会2010年学术交流会
• 发表日期: 2010年期

　　Highly malignant human gliomas over-express a G protein coupled chemoattractant receptor FPR,which,upon activation,promotes tumor cell migration,growth and the production ofangiogenic factors.Our previous studies showed that necrotic glioblastoma cells release chemotactic agonist(s) that activate FPR on live tumor cells.In this study,we examined the nature ofFPR agonist(s) released by necrotic human glioblastoma cells.We found that necrotic tumor cell supernatant contained annexin1,a chemotatic polypeptide agonist for FPR,as well as a potential agonist for the FPR variant FPRL1.