【摘 要】
：
To introduce a modified method,namely coaxial electrohydrodynamic atomization for the fabrication of distinct core/shell structured microspheres of four first-line ant-tuberculosis drugs with differen
【机 构】
：
Department of Spine Surgery, The Xiangya Hospital of Central South University, 87＃ Xiangya Road, Cha
【出 处】
：
第三届全国脊柱结核诊疗新技术研讨会暨2017年湖南省医学会脊柱外科专业委员会年会
论文部分内容阅读
To introduce a modified method,namely coaxial electrohydrodynamic atomization for the fabrication of distinct core/shell structured microspheres of four first-line ant-tuberculosis drugs with different characteristics in hydrophilic properties in one single step.In group B,we prepared microspheres in which the core and the shell contain hydrophobic and hydrophilic drugs,respectively.In contrast,in group C,the opposite is prepared.The detec-tion of encapsulation efficiency and in vitro release test were performed to confirm the feasibility of the drug-loaded core/shell structured microspheres.Moreover,cell culture experiments and animal experiments have been carried out to evaluate the biological safety of different microspheres in cell growth,cell viability,osteogenesis and migra-tion of BMSCs in vitro and the bone fusion in a bone deficits model in SD rat.Meanwhile,the distribution of drugs and liver and kidney toxicity were monitored.The release patterns of the two groups are significantly different.The release of drugs from Group B microspheres is rather sequential,whereas group C microspheres release drugs in a parallel (co-release) manner.And various concentrations of carrier materials produces core/shell structured microspheres with different appearance.Moreover,the biological safety of core/shell structured microspheres was testified to be satisfactory.These findings present the advantages and possible application of this kind of multi-drug release system in treating skeletal tuberculosis.Moreover,the characteristic sequential release of multi-drugs can be controlled and adjusted based on treatment need and used in treating other disorders.
其他文献
Purpose Aged patients represent a high risk group for acquir-ing spinal tuberculosis,and it still remains a leading cause of kyphosis and paraplegia in developing nations.Aged patients often combined
Purpose There are few papers in the literature comparing out-comes between antero-posterior and posterior-only ap-proaches for treating thoracolumbar tuberculosis (T10-L2) in children Methods We perfo
Purpose The purpose of this study was to determine the effi-cacy and feasibility of surgical management of children with thoracolumbar spine tuberculosis with kyphosis by using one-stage posterior foc
Objective: The current study compared clinical outcomes of two diverse therapeutic strategies for upper thoracic (T1-4) spinal tuberculosis with neurological deficits in elderly patients.Methods: A re
Aim: The aim of this retrospective clinical study is to evaluate the long-term outcomes for single-stage transpedicular debridement,posterior instrumentation and fusion in the management of thoracic a
Non-Hodgkin lymphoma (NHL) is one of the most common hematologic malignancies among adults for which the chimeric monoclonal anti-CD20 antibody (Ab) rituximab (RTX) is used as first-line therapy.As RT
BACKGROUND CONTEXT: The single-stage posterior approach only for spinal tuberculosis (TB) has been reported by some surgeons recently,but few studies have reported single-stage trans-pedicular decompr
Objective The purpose of this study was to evaluate the out-comes of computed tomography (CT) guidance using percu-taneous catheter with low-dose drainage local chemotherapy (modified PCD) and antitub
Objective The purpose of this study was to investigate the clinical efficacy and feasibility of one-stage posterior fixation,anterior debridement,bone grafting and anterior fixation for multiple cervi
Purpose The purpose of this study was to evaluate the clinical and radiographic outcomes of modified pedicle subtraction osteotomy (mPSO) for thoracolumbar post-tubercular kypho-sis in pediatric patie