论文部分内容阅读
A wide variety of stimuli have been shown to induce inflammation,but bacteria products/components are considered the major inducers during bacterial infections.We previously found that bacterial products/components such as lipopolysaccharide (LPS),a glycolipid component of the bacterial outer membrane,and formylated peptides (fMLP),a bacterial derived peptide,induced pro-inflammatory cytokine gene expression in human peripheral blood monocytes.We now present evidence that mixtures of bacterial products/components behave synergistically in the induction of inflammation in vitro and in vivo.Our results indicate that the IKK β/I κBα/NF-B signaling pathways are involved in the synergistic induction of inflammatory cytokines by bacterial products.These results demonstrate an important role for bacterial products/components from lysed bacteria in the pathogenesis of infectious diseases.These results also suggest that the control of inflammation is likely best understood at the level of synergistic regulation of intracellular signaling molecules.We believe that this synergy represents an important pathogenic mechanism during bacterial infection,which may suggest novel therapeutic strategies or targets to minimize host injury following bacterial infection.