The transient ion-pair species captured in the oxidation process of DNA Guanine

来源 :中国化学会生物物理化学专业委员会第四届全国生物物理化学会议 | 被引量 : 0次 | 上传用户:ytx45
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
  Understanding the reaction mechanism of Guanine(G)in DNA with oxidant radicals is imperative when trying to elucidate the potential oxidation damage on DNA.Previously,a pathway was theoretically suggested that includes an ion-pair intermediate.However,up till now,such an ion-pair intermediate has not been observed experimentally due to its expected instability.
其他文献
  The β-barrel outer membrane proteins(OMPs)are located on the outer membrane of Gram-negative bacteria with biological significance.SurA protein has been id
会议
  The major driving force of protein folding depends on their inter-residue interactions,especially for sidechain-sidechain interactions.Although the Trp-cage
会议
  As the most important transmembrane signaling modulator,G protein-coupled receptors(GPCRs)are the most valuable therapeutic targets while GPCR-targeting dru
会议
  Single-molecule fluorescence measurements have been widely used to explore kinetics and dynamics of biological systems.Among them,single-molecule imaging(SM
会议
  Carotenoids are important nutrients with antioxidative properties.Serum albumin is the most abundant protein in blood plasma and serves as a depot and trans
会议
  Foldamers,defined as artificial molecular architectures inspired by the structures and functions of biopolymers,have been a hot button in supramolecular che
会议
  Here,we have prepared a FePt/GO-based nanocomposite as a potential targeted theranostic agent for cancer treatment.Using the FA targeting function and FePt
会议
  在正常的生理条件下,DNA 主要是以Watson-Crick 碱基配对的形式,以右手双螺旋的结构存在,这类经典的DNA结构被称为B-DNA.然而,具有重复碱基的DNA序列在一定的条件下会折
  功能成像(PET 或SPECT)与结构成像(CT 或MRI)的有机结合是目前疾病诊断的发展趋势之一,能有效提高疾病诊断的准确度 [1,2]。在本研究中,我们采用RGD 多肽、聚乙二醇和DTP
  生物体内糖配体与蛋白之间可以通过多价效应的协同作用增强它们之间的亲和性、特异性,产生所谓的“多价效应”1.生物系统中的多价作用的强度可能比一个低分子量的配体与一