Enantioselective Synthesis of Functionalized 3,4-Disubstituted Dihydro-2(1H)-quinolinones via Michae

• 作 者: Xiao-longZhang;Cheng-keTang;Xue-liLiu;Dan-qianXu;
• 机 构: Zhejiang University of Technology Hangzhou 310014
• 出 处: 中国化学会第九届全国有机化学学术会议
• 发表日期: 2015年期

　　A new method is developed for the enantioselective synthesis of highly functionalized 3,4-disubstituted dihydro-2(1H)-quinolinones bearing two syn contiguous stereogenic centers with excellent diastereoselectivities(up to >99:1 dr)and high to excellent enantioselectivities(up to >99%ee).