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AIM:To study the pharmacokinetics of abrin P2 in mice, as the basis for developing new anti-cancer drug.METHODS: 125I-abrin P2 was administered orally 43.8μg·kg-1.Blood samples were collected at several different time points following drug administration, and then the plasma was separated from blood samples, Radioisotopie tracing method combined with trichloroacetic acid (TCA) precipitation was used to determine plasma concentration of 125I-abrin P2 in mice.The pharmacokinetic parameters were calculated using PKS software.Tissue distribution and the excretion of 125I-abrin P2 were studied in mice at different periods.