Global end-diastolic volume index vs.central venous pressure goal-directed fluid resuscitation for s

• 作 者: 於江泉
• 机 构: 苏北人民医院
• 出 处: 2015年中国长江医学论坛——重症医学与医学发展暨江苏省第六届重症医学大会
• 发表日期: 2015年3期

Purpose: To investigate the clinical effects of early goal-directed therapy according to GEDI on septic shock associated with COPD.Methods: 71 patients with COPD-associated septic shock were randomly assigned to 2 groups.In the control group (n=37), fluid resuscitation was performed based on the CVP.In the study group (n=34),fluid resuscitation was performed until GEDI to 800 mL/m2.The following indices were observed for the 2 groups:6-and 24-h fluid volumes, norepinephrine dosage, 24-h blood lactate clearance rate,duration of mechanical ventilation, ICU length of stay,ICU mortality, 90-d survival rate.Results: Whether 6 h or 24 h, the fluid volume was lower,norepinephrine dosage was higher in the control group than in the study group (P＜0.05).The blood lactate clearance rate was lower, The duration of mechanical ventilation was longer, and the length of stay in ICU was longer in the control group than in the study group (P＜0.05).There was no significant difference in mortality or 90-day survival rate between the 2 groups.Conclusions: GEDI goal-directed fluid resuscitation shows better clinical effects than CVP to COPD-associated septic shock patients.