The role of desensitization of G-protein-activated inward rectifier potassium (GIRK) channels in the

• 作 者: Ying-Ying WANG Jiong QIN Ying HAN Jie CAI Guo-Gang XING
• 机 构: Department of Pediatrics, Peking University First Hospital Beijing 100034, China
• 出 处: 中国神经科学学会第九届全国学术会议暨第五届会员代表大会
• 发表日期: 2011年1期
• 关键词: febrile seizures epileptiform discharges hyperthermia GABAB receptors GIRK chann

　　Febrile seizures (FS), or fever-induced seizures, are the most common form of seizures during childhood and have been associated with an increased risk of epilepsy later in life.It has been suggested that hyperthermia (temperature of ≥38.4 ℃) during fever plays a crucial role in generation of FS.However, the mechanisms underlying the pathogenesis of hyperthermia-induced seizures are poorly understood.In previous studies, we and others have suggested that GABAB receptors are likely to be associated with FS.In this study, by using whole-cell patch-clamp recording techniques, we demonstrated that hyperthermia (39-40 ℃) provoked a "febrile seizure-like event" expressed as spontaneous, recurrent, epileptiform discharges (SREDs) followed by a series of sustained depolarizations (SDs) in cultured rat cortical neurons (7-14 DIV).