Role of integrinα(v)β3 in the differentiation of human hypertrophic scar fibroblasts when induced by

• 作 者: XiaolongHu;WeixiaCai;XiaozhiBai;XiongxiangZhu;JuntaoHan;DahaiHu;NaLi;KeTao;XiaobingFang;YaojunWang;JiaqiLiu;JihongShi;YunchuanWang;PengJi;
• 机 构: Department of Burns and Cutaneous Surgery,Xijing Hospital,Fourth Military Medical Unirrersity,127 Ch
• 出 处: 第十届全国烧伤救治专题研讨会暨福建省第八次烧伤外科学术研讨会
• 发表日期: 2013年期

　　CCN2 is a matricellular protein that appears to be important in scar formation CCN2 mediates the pro-fibrotic effects in hypertrophic scars(HTSs)through an unknown mechanism;however,many activities of CCN2 protein are known to be mediated through direct binding to integrin receptors In this study,we investigated the role of integrin α(v)β3 in differentiation of hypertrophic scar fibroblasts口TSF)induced by CCN2 First.we compared the levels of integrin α(v)β3 between normal skin and hypertrophic scar(HTS)tissues and found that integrin α(v)β3 was up-regulated 1n HTS Second.