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Background: The standard recommended method for surgical treatment of spinal tuberculosis is an anterior approach for debridement and fusion combined with posterior instrumentation.However,the method has its disadvantages.The aim of this study was to analyze the effectiveness and safety of treating thoracic and lumbar spinal tuberculosis with debridement,internal fixation reconstruction,and using specially formed titanium mesh cages via a posterior-only approach.Methods: The authors retrospectively reviewed the cases of 28 patients with spinal tuberculosis treated by debridement,internal fixation,and reconstruction with a specially formed titanium mesh cage via a posterior-only approach.The levels involved were less than two contiguous vertebrae: 13 thoracic vertebrae,5 thoracolumbar vertebrae,and 10 lumbar vertebrae.All patients suffered from back pain,and nine patients had neurologic deficits (two were class C and seven were in class D according to the American Spinal Injury Association classification).All patients were followed up every 3 months after surgery,with a minimum 48-month follow-up.The clinical efficacy was evaluated based on the visual analog scale (VAS),the Oswestry Disability Index (ODI),neurological status,kyphosis angle,and erythrocyte sedimentation rate (ESR).Results: All patients obtained solid bony fusions without failure of fixation.The infections were resolved in all patients,as noted by normalization of their ESR.The average surgery time was 2 h and 15 min,with an average blood loss of 435 ml.The VAS scores dropped from a preoperative level of 6.31 ± 1.25 to the final follow-up level of 0.57 ± 0.14.The ODI scores dropped from 39.14± 12.38 preoperatively to 7.29 ± 3.09 at 1 year postoperatively and 6.77 ± 2.53 at final follow-up.The kyphosis Cobbs angle was corrected from 22.31 °± 4.26° preoperatively to 5.86° ± 0.57° at final follow-up.No subsidence of titanium mesh cage or posterior instrumentation failure was observed postoperatively.The neurological outcome increased by 1-2 grades in the patients with neurological deficits.Conclusions: Debridement,internal fixation,and reconstruction using specially formed titanium mesh cages via a posterior-only approach is effective and safe for treating adults with thoracic and lumbar spinal tuberculosis involving less than two contiguous levels.