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Recently,a major challenge in nanomedicine for cancer drug delivery is to engineer nanostructures which can efficiently load drugs with high concentration,cross the cell membrane,and controllably release the cargos at the target site.Here,we report a classes of smart nanocarriers based on mesoporous silica nanoparticles(MSNs)and PAMAM to achieving high targeting specificity and delivery efficiency,avoiding nonspecific binding and entrapment by the bodys defences.