The BCL2 Gene Regulated by a Special AT-rich Sequence Binding Protein 1(SATB1)-mediated Long-range C

• 作 者: GONGFei-ran[1]SUNLuan[1]WANGZong-dan[1]SHIJun-feng[1]LIWei[2]WANGSu-meng[1]HANXiao[2]SUNYu-jie[3]
• 机 构: Key Laboratory of Human Functional Genomics of Jiangsu Province
• 出 处: 中华医学会医学细胞生物学分会第三届全国学术会议
• 发表日期: 2011年期

　　The proto-oncogene BCL2 was first cloned from the t(14; 18) translocation breakpoint in human follicular B-cell lymphoma.It is about 250 kDa in length and composed of three exons and two promoters (1).The BCL2 protein is a key regulator of apoptosis and is additionally involved in DNA repair, cell cycle and differentiation control.Given its fundamental importance for the cellular fate, BCL2 expression is finely tuned by a variety of environmental and endogenous stimuli and regulated at both transcriptional and posttranscriptional levels.Our previous report has demonstrated that the major breakpoint region (mbr) within the 3-UTR of the BCL2 gene that is 200 kb downstream of the promoter,is a transcriptional regulatory element and stimulates BCL2 genes activity.