Human biliverdin reductase promotes EMT through the ERK1/2 signal pathway in breast cancer

• 作 者: Min Zhang Shasha Song Zhi Yi Xijuan Zhao Li Fu Lin Wang Cui Ma Min Mao Yan Xing Daling Zhu
• 机 构: Department of Biopharmaceutical Sciences,College of Pharmacy,Harbin Medical University(Daqing),Daqin
• 出 处: 2016年国际生理学学术大会
• 发表日期: 2016年6期

　　Epithelial-to-mesenchymal transition(EMT)plays an important role in the development of the invasive and metastatic potentials of breast cancer cells during progression.Human biliverdin reductase(hBVR),an enzyme in the heme metabolism pathway,is involved in hypoxia-induced renal tubular EMT.However,whether hBVR contributes to the EMT of breast cancer remains unclear.