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Aim: To explore the relationship between plasma total homocysteine concentration and diabetic neuropathy in Chinese patients with type 2 diabetes.Methods: Chinese patients with type 2 diabetes (n=249) were enrolled in a cross-sectional hospital based study.Diabetic neuropathy staus was documented by presence of clinical signs and confirmed by electromyography.Plasma total homocysteine concentration was measured using fluorescence polarization immunoassay.Traditional risk factors for diabetic neuropathy were obtained from fasting blood samples and interviewer-questionnaire.