SEC2 mutant drives T lymphocyte activation through PI3K/mTOR and NF-κB signaling pathways

来源 :中国生物化学与分子生物学会第十二届会员代表大会暨2018年全国学术会议 | 被引量 : 0次 | 上传用户:wangzu03
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  Staphylococcal enterotoxin C2(SEC2)causes rapid clonal expansion of lymphocytes and secretion of T cell growth factors,leading to a severe inflammatory response within tissues.Our previous studies constructed a SEC2 mutant ST-4 with enhanced recognition of Vβ regions of T-cell receptors,which can activate increased number of T cells and produce more cytokines than SEC2.
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