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Objective It has been discovered that the major reason for MDR in cancer is the overexpression of P-glycoprotein (P-gp), a product of the human MDR1 gene.Recent studies have demonstrated that in cancer cells with MDR, the expression levels of cyclo-oxygenase-2 (Cox-2) and an isoform of protein kinase C (PKC-α) are both upregulated.The aim of the present study is to evaluate the antineoplastic effect of PAB in vivo, using a xenograft model in nude mice and explore PABs underlying molecular mechanism involved in the reversal of MDR.