Biodistribution, Persistence and Neurotoxicity of Ceria Engineered Nanomaterials

• 作 者: MoDan;RobertA.Yokel;LiLiu;ZuogangLi;JufengWang;BoLi;
• 机 构: National Center for Safety Evaluation of Drugs,National Institutes for Food and Drug Control,Beijing
• 出 处: 第四届药物毒理学年会
• 发表日期: 2014年期

　　Objective ceria engineered nanomaterials(ENMs)have utility in the treatment of neurodegenerative disorders by reducing reactive oxygen species(ROS)(1,2).However,as it is known that insoluble nanomaterials are not readily eliminated and long term and delayed effects of nanoceria have not been very well studied.The objectives of the present research were to ascertain the effect of ENM size on the longer term fate and toxicology effects of the 4 sizes of citratE-coated ceria ENMs into selected organs,including the brain up to 30 days(720 h)after a single iv ceria ENM infusion.