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The influence of addictives on the hydrothermal formation of hemi-hydrate calcium sulfate (CaSO4·0.5H2O) whiskers were discussed in this paper, using CaCl2 and Na2SO4 as the reactants.The presence of NaCl, CaCl2 or NaSO4 increased the concentrations of Ca2+ and SO42-, leading to the formation of CaSO4·0.5H2O whiskers with low aspect ratio (<50).The one dimensional growth of CaSO4·0.5H2O whiskers was enhanced in water without additives owing to the low super-saturation, leading to the formation of uniform whiskers with a length of 200-2000μm and high aspect radio(>100).