OG-PP73:Nanoparticles Prepared from Novel Amphiphilicβ-Cyclodextrins

• 作 者: ZHANG Hua-Cheng ZHAO Ming-Gang SHEN Jian SUN Hong-Yuan AN Wei HAO Ai-You
• 机 构: School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, P.R.China
• 出 处: 第13届亚洲化学大会(13th Asian Chemical Congress)
• 发表日期: 2009年12期
• 关键词: Cyclodextrins synthesis amphiphilic microcapsules self-assembly

　　Novel amphiphilic β-cyclodextrins1 (β-CDs),6-O-(dodecyloxy-2-hydroxypropyl)-2-O-(2-hydroxypropyl)-β-cyclodextrin (1),6-O-(tetradecyloxy-2-hydroxypropyl)-2-O-(2-hydroxypropyl)-1β-cyclodextrin (2),6-O-(hexadecyloxy-2-hydroxypropyl)-2-O-(2-hydroxypropyl)-β-cyclodextrin (3) and 6-O-(octadecyloxy-2-hydroxypropyl)-2-O-(2-hydroxypropyl)-β-cyclodextrin (4) were designed and synthesized in about 10% yield.These structures (1~4) were characterized and confirmed by 1H-NMR,13C-NMR, and ESI-MS.The average substituted degrees of hydroxypropyl groups and alkoxyl groups,calculated according to literatures2, were about six and two, respectively.Nanoparticles were prepared from these novel amphiphilic β-CDs (1~4) by ultra-sonicating.