【摘 要】
：
雄黄(Realgar)始载于《神农本草经》,是中医最早使用的矿物药物之一,主要成分为二硫化二砷(As2S2)。从20世纪六十年代开始,雄黄在临床上被用于治疗急性粒细胞性白血病(AP
【机 构】
：
中国医学科学院基础医学研究所;北京协和医学院基础学院生物医学工程学系中国石油大学(北京)理学院能源材料微结构实验室北京化工大学材料科学与工程学院国家碳纤维工程技术研究中心
【出 处】
：
2013全国生物与医学纳米技术博士生学术论坛
论文部分内容阅读
雄黄(Realgar)始载于《神农本草经》,是中医最早使用的矿物药物之一,主要成分为二硫化二砷(As2S2)。从20世纪六十年代开始,雄黄在临床上被用于治疗急性粒细胞性白血病(APL)和慢性粒细胞性白血病(CML),并取得了较好的疗效。已有的研究表明,雄黄治疗白血病作用机理是As2S2可以特异性的激活泛素连接酶E3,并最终通过E3家族中c-CBL作用将异常融合蛋白BCR-ABL或PML-RAR泛素化降解,从而抑制白血病细胞的增殖,并促进其凋亡或向正常细胞分化。但是,雄黄在临床应用中面临一个重要的挑战就是水溶性极低,导致其生物利用度难以提高。
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