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Ostevporosis is a disease affecting more than 75 million people in the United States，Europeand Japan，resulting in over 7.1 million fractures annually globally. Of these fractures,half occur in Europe，North and South America. The life-time risk far a wrist，hip orvertebral fracture in a Caucasian pastmenopaussl woman is approximately 40％，similar infrequency to coronary heart disease.