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Elevated iron levels in the substantia nigra participate in neuronal death in Parkinsons disease (PD).While the mechanisms underlying the increased iron are still unknown,some iron transport proteins may be involved.Ceruloplasmin (CP) is a ferroxidase that converts highly toxic ferrous iron to its non-toxic ferric form,which cooperated with ferroportinl (FP1) facilitating the export of iron from reticuloendothelial system and other peripheral tissues.Previous study showed that decreased expression of FP1 in the substantia nigra can account for the increased iron levels.To elucidate if the abnormal expression of CP is also involved in the nigral iron accumulation,here,we investigated CP expression in the substantia nigra of rats lesioned by 6-hydroxydopamine (6-OHDA).