Design,Synthesis and Biological Evaluation of Imidazo[1,2-b]pyridazine Diaryl Ureas Derivatives

• 作 者: Shan-YunGao;YunWu;Yi-RanWeng;Yao-KaiDuan;Liang-RenZhang;
• 机 构: State Key Laboratory of Natural and Biomimetic Drugs,School of Pharmaceutical Sciences,Peking Univer
• 出 处: 第九届IUPAC化学生物学国际研讨会暨第八届世界华人药物化学研讨会
• 发表日期: 2012年期

　　Receptor tyrosine kinases(RTKs) play a vital role in cell proliferation,metabolism,survival,and apoptosis [1,2] According with a pharmacophore based scaffoldhoppingand bioisosterism strategy,imidazo[1,2-b]pyridazine diaryl ureas derivatives(scheme 1) were developed.