【摘 要】
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Objective: Adipose tissue derived stem cell (ADSCs) transplantation has shown great promises for enhancing skin repair in animal models of diabetic skin wound healing.However, poor viability of transp
【机 构】
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Department of Stem Cells and Reproductive Medicine, Key Laboratory of Cell Biology,Shenyang 110001,
【出 处】
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第九届全国创伤修复(愈合)与组织再生学术会议暨第二届中欧创面修复学术会议
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Objective: Adipose tissue derived stem cell (ADSCs) transplantation has shown great promises for enhancing skin repair in animal models of diabetic skin wound healing.However, poor viability of transplanted ADSCs in injured diabetic skin has limited the therapeutic efficiency.Advanced glycation end products (AGEs) and oxidative stress is one of major mechanisms underlying the pathogenesis of diabetic skin wound healing and has a negative impact on the survival of transplanted ADSCs.This study aims to explore the effect of advanced glycosylation end products (AGEs) on oxidative stress of ADSCs in vitro and the underlying mechanism.
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