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Methods/design: This study is a prospective,multi-centre,randomized,double-blinded,parallel group,placebo-controlled trial.A total of 420 adult participants with acute pharyngitis of either gender will be enrolled from seven study sites across China.All participants are randomly allocated to one of three parallel treatment groups: QWQYA with the present propellant,QWQYA with the previous propellant,and the placebo aerosol with the present propellant.The study medication will be administered into the pharyngeal region 3 sprays three times daily for 5 consecutive days.The primary outcomes are time to complete resolution of sore throat and relief rate of sore throat.Secondary outcomes include resolution rate of sore throat,time to relief of sore throat,intensity of sore throat,change of traditional Chinese medicine syndrome score and clinical signs score from baseline to post-treatment,as well as adverse events.Discussion: This will be the first clinical trial to investigate the efficacy and safety of QWQYA in the treatment of acute pharyngitis in an adult population in a multi-centre,randomized,double-blinded,parallel group,placebo-controlled manner.It may not only establish the basis for the efficacy and safety of QWQYA in treating acute pharyngitis,but also provide the evidence regarding Chinese herbal medicine for treating acute pharyngitis and an alternative treatment option for the management of acute pharyngitis.