Amino Acids and Peptides Based Cationic Liposomes Mediated Gene Transfer

• 作 者: 轶男赵 韶晖崔 会英陈 树彪张
• 机 构: 大连民族大学
• 出 处: 2015中国化工学会学术年会
• 发表日期: 2015年12期
• 关键词: Non-viral vectors Cationic liposomes Amino Acids Peptide Gene delivery

Gene therapy requires safe and efficient carriers to transfer expressible genetic materials or silencing nucleic acids to target tissues.The most extensively used delivery tools can be generally divided into two categories,viral vectors and non-viral vectors.Some side effects including immunoresponse and infection have been reported,and it was relatively difficult to get a large number of recombinant viral vectors.Non-viral gene delivery systems have,on one hand,been demonstrated as standard tools for in vitro transfection with currently more than 60 commercially available kits.On the other hand,they are regarded as a promising approach for the treatment of genetic diseases and cancers.As an important type of nonviral gene vector,amino acids and peptide-based cationic liposomes have shown many advantages over come cationic liposomes,such as good biodegradability,excellent biocompatibility and targeting ability to cells,and great potential application in improving the delivery of gene therapeutics.Based on the study of recent years,this article summarizes the latest development of amino acids and peptide-based cationic liposomes for gene delivery,including the structure characteristics of peptide lipids,the development of peptide cationic liposomes and three types of peptide cationic liposomes,peptide-based Gemini lipids,lipitoids,lipids with cholesterol hydrophobic group.The review hopes to provide some suggestions on the design of peptide cationic lipids and insight into their development trend in the field of gene delivery.