NFKB signaling initiates early differentiation of neural stem cells through repressing C/EBP

• 作 者: YonggangZhang[1]WentongMeng[1]ShuLiu[2]LeitingYang[2]ShaffiatKarmally[3]JinLiu[1]HongyanZhu[1]JenniferGordon[2]KamelKhalili[2]ShanthiSrinivasan[4]JohnR.Bethea[3]JianjunLiu[2]WenhuiHu[2]XianmingMo[1]Sh
• 机 构: Laboratory of Stem Cell Biology, State Key Laboratory of Biotherapy, West China Hospital, West China
• 出 处: 中国细胞生物学学会全体会员代表大会暨第十二次学术大会
• 发表日期: 2011年期

　　Inflammatory mediators, many of which activate NFKB signaling, have received increasing attention in neurogenesis.NFKB signaling regulates neurite outgrowth and neural plasticity, as well as the proliferation/apoptosis and terminal differentiation of neural stem cells (NSCs).Here weshow that NFKB signaling is required for NSC initial differentiation.The canonical IKKβ/I Bα/p65 pathway is activated during the initial stages of neural differentiation both in vitro and in vivo.NSC-specific inhibition of NFKB in transgenic mice causes an accumulation of Nestin+/Sox2+/GFAP+ NSCs.