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Objective: Frontal comminuted depressed skull fractures needs special attention due to complications and esthetics.The optimal method of reconstruction and fixation of frontal bone fragments remains a matter of discussion.We explored the advantages of reconstruction of frontal bone with titanium clamps.Patients and methods: From May 2007 to September 2011 we performed 18 cran iotomies with titanium clamps to fix the cranial fragments.On the beginning of cran iotomy, single window craniotomy (n=11) and two windows craniotomy (n=9) were de signed.After dural closure and frontobasal reconstruction, these fragments were fixed with titanium clamps.A helical CT-scan was obtained after operation and a three di mensional technique was performed to evaluate the postoperative results.Results: The craniofix titanium clamp system was applied in 18 patients.No intraop erative and postoperative complications related to clamps were observed.The number of bone fragments ranged from 2 to 5 (average 3.3 pieces) while the number of clamps ranged from 3 to 8 (average 5.8).The time of refixation ranged from 5 to 17 minutes with average 9.4 minutes.Obvious statistical significance (p=0.015) was found in postoperative CT-scan results between single window group and two windows group, although it is no statistical difference in intraoperative subjective valuation (p>0.05).In all 18 cases, the alignment of fragments was precise, the fixation rigid, and the esthetic result satisfying.Conclusions: Reconstruction forehead by refixation of bone fragments with titanium clamps in frorital depressed skull fractures is safe and suitable.This technique promises to be a good alternative in the repair of frontal comminuted depressed skull fractures.The simplicity, reliable fixation and fast handling are its prominent features.