Interleukin 33 is crucial for the accumulation and function of myeloid-derived suppressor cells in t

来源 :第十四届全国肿瘤生物治疗大会 | 被引量 : 0次 | 上传用户:qazxc123
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
  Tumor-induced, myeloid-derived suppressor cells (MDSCs)-mediated immune dysfunction is an important mechanism that leads to tumor immune escape and the inefficacy of cancer immunotherapy.Importantly,tumor-infiltrating MDSCs have much stronger ability compared to MDSCs in the periphery.
其他文献
  研究背景:急性髓系白血病是一种常见的恶性肿瘤增生性疾病,中位发病年龄为64~70岁,属于老年性疾病。现代的治疗是以联合化疗和造血干细胞移植为主,但大剂量联合化疗后严重
  研究背景:白血病干细胞(leukemia stem cells,LSCs)是白血病发病和复发的根源。靶向根除LSCs的治疗策略具有重要意义。然而,LSCs通常具有化疗抵抗性,常规化疗无法根治白血
  Objective: The epidermal growth factor receptor pathway substrate 8 (EPS8) plays a critical role in the proliferation, progression and metastasis of solid a
会议
  BACKGROUND:Non-Hodgkin's Lymphoma is one of the highly invasion tumor in hematology, with the amazing growth rate and complex pathology characteristics.More
会议
  目的:研究肿瘤坏死因子α(TNF-α)诱导下,膀胱癌细胞中NF-κB通路分子的表达变化及其对细胞增殖水平的影响。方法:50 ng/ml TNF-α分别处理T24、5637膀胱癌细胞株,应用实时
  Fas是经典的凋亡信号,几乎所有的肿瘤均表达Fas,但多数肿瘤Fas信号的活化不引起细胞凋亡,却促进其进展,研究显示肺癌细胞Fas信号的活化不诱导细胞凋亡,却通过促进其招募
  目的:探讨TEX在活化DCs,增强机体抗肿瘤免疫反应的同时是否可通过促进DCs分泌前炎症因子,从而促进肿瘤的转移。方法:通过分级分离及超速离心制备TEX,体外刺激DCs,流式检测
  Toll-like receptor (TLR) 4-mediated signaling has been shown to be important to tumor cell survival,invasion and metastasis in a variety of cancers.The pres
会议
  Increased expression of galectin-1 (Gal-1) in carcinoma-associated fibroblasts (CAFs) has been reported to correlate with progression and prognosis in many
会议
  Metastasis is responsible for more than 90% of the mortality observed among patients with breast cancer.Human phosphatidylethanolamine-binding protein 4 (hP