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Leptospirosis,caused by pathogenic species of genus Leptospira,has emerged as the most widespread zoonotic disease worldwide.During the early period of leptospiral infection,the innate immune system plays a key role in clearing leptospires which can be recognized by macrophages in blood or tissue.Although scavenger receptor A (SR-A) is one of the most important pattern recognition receptor for macrophages,there still are no reports addressing the interaction between leptospires and SR-A.In this study,SR-A expression was significantly increased in primary murine bone marrow derived macrophages (BMDMs) following the infection with L.interrogans strain 56606v.