【摘 要】
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Objectives To investigate the effects of angiotensinⅡ (AngⅡ) and angiotensin-(1-7) [Ang-(1-7)] on scavenger receptor class B type1 (SR-BI), ATP-binding cassette transporter A1 (ABCA1) and cholesterol
【机 构】
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Department of Cardiology,The Second Hospital of Shanxi Medical University
【出 处】
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第二十四届长城国际心脏病学会议、亚太心脏大会暨国际心血管病预防与康复会议(The 24th Great Wall Int
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Objectives To investigate the effects of angiotensinⅡ (AngⅡ) and angiotensin-(1-7) [Ang-(1-7)] on scavenger receptor class B type1 (SR-BI), ATP-binding cassette transporter A1 (ABCA1) and cholesterol efflux in THP-1 derived foam cells.Methods Human monocytic cell line (THP-1) was induced intomacrophages by100 nmol/L phorbol myristate acetate (PMA) for 48h, and treated with ox-LDL to construct the foam cells, then were randomly allocated into five groups: control group, AngⅡ group,Ang-(1-7) group, Ang-(1-7) + AngⅡ groupand AngⅡ + Ang-(1-7) + A-779 group.
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