Rational engineering of plasticity residues of sesquiterpene synthases from Artemisia annua: product

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Most terpene synthases contain plasticity residues that are responsible for diversified terpene products and functional evolution,which provide a potential for improving catalytic efficiency.Artemisinin,a sesquiterpene lactone from Artemisia annua L.,is widely used for malaria treatment and progress has been made in engineering the production of artemisinin or its precursors.
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